Pesquisa | SciELO

Abstract Objective: To develop a convolutional neural network (CNN) model, trained with the Brazilian “Estudo Longitudinal de Saúde do Adulto Musculoesquelético” (ELSA-Brasil MSK, Longitudinal Study of Adult Health, Musculoskeletal) baseline radiographic examinations, for the automated classification of knee osteoarthritis. Materials and Methods: This was a cross-sectional study carried out with 5,660 baseline posteroanterior knee radiographs from the ELSA-Brasil MSK database (5,660 baseline posteroanterior knee radiographs). The examinations were interpreted by a radiologist with specific training, and the calibration was as established previously. Results: The CNN presented an area under the receiver operating characteristic curve of 0.866 (95% CI: 0.842-0.882). The model can be optimized to achieve, not simultaneously, maximum values of 0.907 for accuracy, 0.938 for sensitivity, and 0.994 for specificity. Conclusion: The proposed CNN can be used as a screening tool, reducing the total number of examinations evaluated by the radiologists of the study, and as a double-reading tool, contributing to the reduction of possible interpretation errors.

Resumo Objetivo: Desenvolver um modelo computacional - rede neural convolucional (RNC) - treinado com radiografias da linha de base do Estudo Longitudinal de Saúde do Adulto Musculoesquelético (ELSA-Brasil Musculoesquelético), para a classificação automática de osteoartrite dos joelhos. Materiais e Métodos: Trata-se de um estudo transversal abrangendo todos os exames da linha de base do ELSA-Brasil Musculoesquelético (5.660 radiografias dos joelhos em incidência posteroanterior). Os exames foram interpretados por médico radiologista com treinamento específico e calibração previamente publicada. Resultados: A RNC desenvolvida apresentou área sob a curva característica de operação do receptor de 0,866 (IC 95%: 0,842-0,882). O modelo pode ser calibrado para alcançar, não simultaneamente, valores máximos de 0,907 para acurácia, 0,938 para sensibilidade e 0,994 para especificidade. Conclusão: A RNC desenvolvida pode ser utilizada como ferramenta de triagem, reduzindo o número total de exames avaliados pelos radiologistas do estudo, e/ou como ferramenta de segunda leitura, contribuindo com a redução de possíveis erros de interpretação.

https://doi.org/10.1590/0100-3984.2023.0020-en

Development of a convolutional neural network for diagnosing osteoarthritis, trained with knee radiographs from the ELSA-Brasil Musculoskeletal
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Domingues, Júlio Guerra

; Araujo, Daniella Castro

; Costa-Silva, Luciana

; Machado, Alexei Manso Corrêa

; Machado, Luciana Andrade Carneiro

; Veloso, Adriano Alonso

; Barreto, Sandhi Maria

; Telles, Rosa Weiss

Radiologia Brasileira

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2023, Nº ahead

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/0100-3984.2023.0020-en

Emotional, hyperactivity and inattention problems in adolescents with immunocompromising chronic diseases during the COVID-19 pandemic
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Campos, Reinan T.

; Lindoso, Livia

; Sousa, Renan A. de

; Helito, Alberto C.

; Ihara, Bianca P.

; Strabelli, Claudia A.A.

; Paradelas, Levi M.V.

; Carneiro, Beatriz O.L.

; Cardoso, Maria Paula R.

; Souza, Jean Paulo V. de

; Freire, Marianna R. de M.

; Astley, Camilla

; Laurentino, Moisés F.

; Buscatti, Izabel M.

; Kozu, Katia

; Aikawa, Nadia E.

; Sallum, Adriana M.E.

; Ferreira, Juliana CO.

; Simon, Juliana R.

; Viana, Vivianne S.L.

; Queiroz, Ligia B.

; Gualano, Bruno

; Roschel, Hamilton

; Pereira, Rosa Maria R.

; Toma, Ricardo K.

; Watanabe, Andréia

; Grangeiro, Patricia M.

; Casella, Caio B.

; Farhat, Sylvia C.

; Polanczyk, Guilherme V.

; Campos, Lucia Maria A.

; Silva, Clovis A.

Clinics

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2023, Volume 78 elocation 100167

Resumo: En | Texto: En | PDF: En

Abstract Objective: To assess factors associated with emotional changes and Hyperactivity/Inattention (HI) motivated by COVID-19 quarantine in adolescents with immunocompromising diseases. Methods: A cross-sectional study included 343 adolescents with immunocompromising diseases and 108 healthy adolescents. Online questionnaires were answered including socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and validated surveys: Strengths and Difficulties Questionnaire (SDQ), Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0). Results: The frequencies of abnormal emotional SDQ scores from adolescents with chronic diseases were similar to those of healthy subjects (110/343 [32%] vs. 38/108 [35%], p = 0.548), as well as abnormal hyperactivity/inattention SDQ scores (79/343 [23%] vs. 29/108 [27%], p = 0.417). Logistic regression analysis of independent variables associated with abnormal emotional scores from adolescents with chronic diseases showed: female sex (Odds Ratio [OR = 3.76]; 95% Confidence Interval (95% CI) 2.00–7.05; p < 0.001), poor sleep quality (OR = 2.05; 95% CI 1.08–3.88; p = 0.028) and intrafamilial violence during pandemic (OR = 2.17; 95% CI 1.12–4.19; p = 0.021) as independently associated with abnormal emotional scores, whereas total PedsQL score was inversely associated with abnormal emotional scores (OR = 0.95; 95% CI 0.93–0.96; p < 0.0001). Logistic regression analysis associated with abnormal HI scores from patients evidenced that total PedsQL score (OR = 0.97; 95% CI 0.95–0.99; p = 0.010], changes in medical appointments during the pandemic (OR = 0.39; 95% CI 0.19–0.79; p = 0.021), and reliable COVID-19 information (OR = 0.35; 95% CI 0.16–0.77; p = 0.026) remained inversely associated with abnormal HI scores. Conclusion: The present study showed emotional and HI disturbances in adolescents with chronic immunosuppressive diseases during the COVID-19 pandemic. It reinforces the need to promptly implement a longitudinal program to protect the mental health of adolescents with and without chronic illnesses during future pandemics.

https://doi.org/10.1016/j.clinsp.2023.100167

Spatial distribution pattern of new leprosy cases under 15 years of age and their contacts in Sobral, Ceará, Brazil
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Linhares, Maria Socorro Carneiro

; Kerr, Ligia Regina Franco Sansigolo

; Kendall, Carl

; Almeida, Rosa Lívia Freitas de

; Klovdahl, Alden

; Frota, Cristiane C.

Ciência & Saúde Coletiva

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Abr 2022, Volume 27 Nº 4 Páginas 1641 - 1652

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste estudo foi analisar o padrão de distribuição espacial de novos casos de hanseníase em menores de 15 anos e seus contatos. Estudo transversal, descritivo, abrangendo características sociodemográficas e análise espacial. Os participantes eram de Sobral, Ceará e o estudo foi realizado entre agosto de 2014 e setembro de 2015. Os contatos foram identificados pelos responsáveis pelas crianças. A soropositividade foi determinada com o antígeno NDO-LID e os casos positivos foram plotados em polígonos de Voronoi. Nove novos casos de hanseníase em menores de 15 anos foram encontrados. O número médio de pessoas que conviviam com os casos foi superior ao número de pessoas que conviviam com contatos não domiciliares. Todos os contatos domiciliares sabiam de outros casos de hanseníase e apresentaram maior taxa de testes soropositivos do que os contatos não domiciliares. Os casos índice residiam nas regiões mais pobres do município e em áreas hiperendêmicas. A análise espacial revelou um agrupamento de infecção subclínica em um raio de 102 metros, sugerindo que a transmissão não domiciliar está relacionada à proximidade com indivíduos soropositivos. Concluindo, a busca por novos casos de hanseníase não pode se restringir aos contatos domiciliares.

Abstract This study’s objective was to analyze the spatial distribution pattern of new leprosy cases under 15 years and their contacts. A cross-sectional descriptive study covering sociodemographic characteristics and spatial analysis was carried out. The participants were from the city of Sobral, Ceará and the study was conducted between August 2014 and September 2015. Contacts were identified by the persons responsible for the children. Seropositivity was determined with the NDO-LID antigen, and positive cases were plotted on Voronoi polygons. Nine new cases of leprosy under 15 years of age have been found. The average number of people living with the cases was higher than the number of people living with non-household contacts. All household contacts were aware of other leprosy cases and had a higher rate of seropositive tests than non-household contacts. The index cases lived in the poorest regions of the municipality and hyper-endemic areas. Spatial analysis revealed a cluster of subclinical infection within a radius of 102 meters, suggesting that non-household transmission is related to proximity with seropositive individuals. In conclusion, the search for new leprosy cases cannot be restricted to household contacts.

https://doi.org/10.1590/1413-81232022274.06902021

Spatial distribution pattern of new leprosy cases under 15 years of age and their contacts in Sobral, Ceará, Brazil
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Linhares, Maria Socorro Carneiro

; Kerr, Ligia Regina Franco Sansigolo

; Kendall, Carl

; Almeida, Rosa Lívia Freitas de

; Klovdahl, Alden

; Frota, Cristiane C.

Ciência & Saúde Coletiva

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Abr 2022, Volume 27 Nº 4 Páginas 1641 - 1652

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232022274.06902021

Does [18F]F-FDG-PET/MRI add metabolic information to magnetic resonance image in childhood-onset Takayasu’s arteritis patients? A multicenter case series
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Clemente, Gleice

; Souza, Alexandre W. de

; Leão Filho, Hilton

; Coelho, Fernando M. A.

; Buchpiguel, Carlos

; Lima, Marcos

; Carneiro, Camila

; Pereira, Rosa M. R.

; Aikawa, Nadia

; Silva, Clovis A.

; Campos, Lucia M. A.

; Alves, Gabriel

; Astley, Camilla

; Gualano, Bruno

; Terreri, Maria Teresa

Advances in Rheumatology

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2022, Volume 62 elocation 28

Resumo: En | Texto: En | PDF: En

Abstract Background: The observation that 2-deoxy-2[18F]fluoro-D-glucose-positron emission tomography/magnetic resonance imaging ([18F]F-FDG-PET/MRI) revealed high-grade arterial wall FDG uptake, without arterial wall thickening with contrast-enhancement, in a considerable number of c-TA patients in our previous study, encouraged us to compare patients with both PET and MR angiography (MRA) positives, with those with PET positive but MRA negative. Our aim was to evaluate the relevance of these two imaging modalities together. Methods: A three-center cross-sectional study with 17 patients who fulfilled the EULAR/PRINTO/PReS criteria for c-TA and who underwent [18F]F-FDG-PET/MRI was previously performed. Herein we compared patients/vessels with positive PET (arterial wall 18F-FDG uptake higher than liver) and positive MRA (arterial wall thickening with contrast-enhancement)—group 1, with those with positive PET but negative MRA—group 2. Results: Median disease duration of 17 c-TA patients was 10.4 years. Nine patients were classified as group 1 and six as group 2. Median of metabolic inflammatory volume (MIV) of all arterial segments was significantly higher in group 1 (2346 vs. 1177 cm3; p = 0.036). Fifty-four (19%) from 284 available arterial segments presented positive findings in vessel wall in one or both images. Positive findings were concordant between PET and MRA in only 13% arterial segments (group 1); most changes (28–59.6%) that were discordant between both images, were positive in PET and negative in MRA (group 2). Conclusions: Our study demonstrated that [18F]F-FDG-PET/MRI added information about inflammation in vessel wall of c-TA patients. Prospective multicenter studies are needed in order to get solid data to guide immunosuppressive tapering and withdrawal.

https://doi.org/10.1186/s42358-022-00260-5

Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
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Bensenor, Isabela M.

; Goulart, Alessandra C.

; Pereira, Alexandre C.

; Brunoni, André R.

; Alencar, Airlane

; Santos, Raul D.

; Bittencourt, Márcio S.

; Telles, Rosa W.

; Machado, Luciana Andrade Carneiro

; Barreto, Sandhi Maria

; de Almeida-Pititto, Bianca

; Janovsky, Carolina Porto Silva

; Sgarbi, José Augusto

; Tebar, William R.

; Meneghini, Vandrize

; Barbosa Junior, Fernando

; Ribeiro, Ana Cristina de Medeiros

; Pasoto, Sandra Gofinet

; Pereira, Rosa Maria R.

; Bonfá, Eloísa

; Sipahi, Aytan M.

; Santos, Itamar de S.

; Lotufo, Paulo A.

Clinics

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2022, Volume 77 elocation 100013

Resumo: En | Texto: En | PDF: En

Abstract Objectives This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.

https://doi.org/10.1016/j.clinsp.2022.100013

Hepatitis A and E among immigrants and refugees in Central Brazil
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Silva, Grazielle Rosa da Costa e

; Martins, Thaynara Lorrane Silva

; Silva, Carla de Almeida

; Caetano, Karlla Antonieta Amorim

; Carneiro, Megmar Aparecida dos Santos

; Silva, Bruno Vinicius Diniz e

; Pacheco, Leonora Rezende

; Villar, Livia Melo

; Paula, Vanessa Salete de

; Martins, Regina Maria Bringel

; Teles, Sheila Araújo

Revista de Saúde Pública

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2022, Volume 56 elocation 29

Resumo: En | Texto: En | PDF: En

ABSTRACT OBJECTIVE To estimate the prevalence of hepatitis A virus (HAV) and hepatitis E virus (HEV) among immigrants and refugees in Goiás, Central Brazil. METHODS Overall, 355 individuals were interviewed, and blood samples were tested for anti-HAV and anti-HEV IgG. Anti-HEV-positive samples were similarly tested for HEV RNA. RESULTS All participants were from Latin American countries, most of whom, young adult males. The overall anti-HAV IgG prevalence was 87.4% (95%CI: 83.5–90.4), of whom 94.9%, 75.6%, and 60% were from Haiti, Venezuela, and other Latin American countries, respectively (p < 0.001). Age above 19 years and more than 36 months residing in Brazil were associated with a higher prevalence of previous HAV and HEV infection, respectively. Of the children eligible for HAV vaccination according to the National Immunization Program, only eight (44%) had been vaccinated. The overall anti-HEV IgG prevalence was 6.5% (95%CI: 4.4–9.5). All anti-HEV IgG-positive individuals were Haitians, including a child born in Brazil. HEV RNA was detected in two of the anti-HEV IgG-positive samples. CONCLUSION The survey detected a high prevalence of anti-HAV and anti-HEV IgG among immigrants and refugees, and active HEV infection among some Haitian participants. Prevention measures are urgently required to interrupt enteric virus transmission in this emergent and vulnerable population.

https://doi.org/10.11606/s1518-8787.2022056003839

Hepatitis A and E among immigrants and refugees in Central Brazil
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Silva, Grazielle Rosa da Costa e

; Martins, Thaynara Lorrane Silva

; Silva, Carla de Almeida

; Caetano, Karlla Antonieta Amorim

; Carneiro, Megmar Aparecida dos Santos

; Silva, Bruno Vinicius Diniz e

; Pacheco, Leonora Rezende

; Villar, Livia Melo

; Paula, Vanessa Salete de

; Martins, Regina Maria Bringel

; Teles, Sheila Araújo

Revista de Saúde Pública

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2022, Volume 56 elocation 29

Resumo: En | Texto: En | PDF: En

https://doi.org/10.11606/s1518-8787.2022056003839

10.

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
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Fink, Thais T.

; Marques, Heloisa H.S.

; Gualano, Bruno

; Lindoso, Livia

; Bain, Vera

; Astley, Camilla

; Martins, Fernanda

; Matheus, Denise

; Matsuo, Olivia M.

; Suguita, Priscila

; Trindade, Vitor

; Paula, Camila S.Y.

; Farhat, Sylvia C.L.

; Palmeira, Patricia

; Leal, Gabriela N.

; Suzuki, Lisa

; Odone Filho, Vicente

; Carneiro-Sampaio, Magda

; Duarte, Alberto José S.

; Antonangelo, Leila

; Batisttella, Linamara R.

; Polanczyk, Guilherme V.

; Pereira, Rosa Maria R.

; Carvalho, Carlos Roberto R.

; Buchpiguel, Carlos A.

; Latronico, Ana Claudia

; Seelaender, Marilia

; Silva, Clovis Artur

; Pereira, Maria Fernanda B.

; Sallum, Adriana M. E.

; Brentani, Alexandra V. M.

; Neto, Álvaro José S.

; Ihara, Amanda

; Santos, Andrea R.

; Canton, Ana Pinheiro M.

; Watanabe, Andreia

; Santos, Angélica C. dos

; Pastorino, Antonio C.

; Franco, Bernadette D. G. M.

; Caruzo, Bruna

; Ceneviva, Carina

; Martins, Carolina C. M. F.

; Prado, Danilo

; Abellan, Deipara M.

; Benatti, Fabiana B.

; Smaria, Fabiana

; Gonçalves, Fernanda T.

; Penteado, Fernando D.

; Castro, Gabriela S. F. de

; Gonçalves, Guilherme S.

; Roschel, Hamilton

; Disi, Ilana R.

; Marques, Isabela G.

; Castro, Inar A.

; Buscatti, Izabel M.

; Faiad, Jaline Z.

; Fiamoncini, Jarlei

; Rodrigues, Joaquim C.

; Carneiro, Jorge D. A.

; Paz, Jose A.

; Ferreira, Juliana C.

; Ferreira, Juliana C. O.

; Silva, Katia R.

; Bastos, Karina L. M.

; Kozu, Katia

; Cristofani, Lilian M.

; Souza, Lucas V. B.

; Campos, Lucia M. A.

; Silva Filho, Luiz Vicente R. F.

; Sapienza, Marcelo T.

; Lima, Marcos S.

; Garanito, Marlene P.

; Santos, Márcia F. A.

; Dorna, Mayra B.

; Aikawa, Nadia E.

; Litvinov, Nadia

; Sakita, Neusa K.

; Gaiolla, Paula V. V.

; Pasqualucci, Paula

; Toma, Ricardo K.

; Correa-Silva, Simone

; Sieczkowska, Sofia M.

; Imamura, Marta

; Forsait, Silvana

; Santos, Vera A.

; Zheng, Yingying

Clinics

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2021, Volume 76 elocation e3511

Resumo: En | Texto: En | PDF: En

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

https://doi.org/10.6061/clinics/2021/e3511

11.

Efeito do extrato das folhas da Passiflora edulis na cicatrização da pele em ratos
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Massulo Ribeiro, Laís Silvi

; Rodrigues Rosa Bernardino, Pâmela Cristina

; Blanco, Bruno Anjos

; de Souza e Silva, Thaiany Goulart

; Carneiro Paschoal Bernardes, Maria Tereza

; Pereira, Paulo Sérgio

; Kiss-Ticli, Fábio

; Thomaz de Souza, André Luiz

Avances en Enfermería

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Dez 2020, Volume 38 Nº 3 Páginas 325 - 334

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen Objetivo: Evaluar el efecto del extracto de hoja de Passiflora edulis en la curación de la piel en ratas, específicamente el área de la lesión y de la proliferación de fibroblastos. Materiales y método: Estudio experimental con 54 ratas Wistar macho adultas, divididas por igual en tres grupos. La inducción de lesiones de forma circular en la región dorsocervical se realizó con la ayuda de un punzón de 8 mm. Las lesiones del grupo de control se limpiaron diariamente con agua filtrada y jabón vegetal glicerinado con pH neutro. Los otros dos grupos, además de la limpieza diaria, recibieron tratamiento con crema que contenía extracto al 20 % de las hojas de Passiflora edulis, y crema base sin extracto al 20 % de las hojas de Passiflora edulis, respectivamente. Los días 1, 4, 7 y 14 de tratamiento, se obtuvieron imágenes para calcular el área de la lesión. Los días 4, 7 y 14 de tratamiento, se recolectaron muestras para análisis histológicos. Resultados: No se encontraron diferencias estadísticamente significativas entre los grupos experimentales con respecto a la comparación de las medias del área de la lesión y la proliferación de fibroblastos. Conclusiones: El uso tópico del extracto al 20 % de las hojas de Passiflora edulis no tuvo efecto en el área de la lesión y de la proliferación de fibroblastos en la curación de la piel en ratas.

Abstract Objective: To evaluate the effect of Passiflora edulis leaf extract on skin healing in rats, specially the lesion area and on fibroblast proliferation. Materials and method: Experimental study with 54 male adult Wistar rats equally divided into three groups. The induction of circular-shaped lesions in the dorso cervical region was performed with the aid of an 8 mm climbing punch. Control group lesions were daily cleaned with filtered water and neutral pH glycerinated vegetable soap. The other two groups, in addition to daily cleansing, received treatment with cream containing 20 % extract of Passiflora edulis leaves and base cream without this extract, respectively. On day 1, 4, 7 and 14 of treatment, images were obtained to calculate the lesion area. On day 4, 7 and 14 of treatment, specimens were collected for histological analysis. Results: No statistically significant differences were found between the experimental groups regarding the comparison of means of lesion area and fibroblast proliferation. Conclusion: Topical use of the 20 % extract of Passiflora edulis leaves had no effect on the affected area and the proliferation of fibroblasts on skin healing in rats.

Resumo Objetivo: Avaliar o efeito do extrato das folhas da Passiflora edulis na cicatrização da pele em ratos, especificamente na área da lesão e na proliferação de fibroblastos. Materiais e método: Estudo experimental realizado com 54 ratos da linhagem Wistar, machos, adultos, divididos igualmente em três grupos. A indução das lesões em formato circular na região dorso-cervical foi realizada com o auxílio de um punch trepano de 8 mm. As lesões do grupo de controle foram higienizadas diariamente com água filtrada e sabonete vegetal glicerinado de pH neutro. Os outros dois grupos, além da higienização diária, receberam tratamento com creme contendo extrato a 20 % das folhas da Passiflora edulis, e creme-base sem extrato a 20 % das folhas da Passiflora edulis, respectivamente. No 1°, 4°, 7° e 14° dia de tratamento foram obtidas imagens para cálculo da área de lesão. No 4°, 7° e 14° dia de tratamento foram coletados espécimes para análises histológicas. Resultados: Não foram encontradas diferenças estatisticamente significativas entre os grupos experimentais com relação à comparação de médias da área de lesão e de proliferação de fibroblastos. Conclusões: O uso tópico do extrato a 20 % das folhas da Passiflora edulis não apresentou efeito na área de lesão e na proliferação de fibroblastos na cicatrização da pele em ratos.

https://doi.org/10.15446/av.enferm.v38n3.84534 269 downloads

12.

A percepção da mulher com câncer mamário em relação ao impacto nos filhos
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da Silva Pinto Carneiro, Eliane Cristina

; Costa Rosa Andrade Silva, Rose Mary

; Ramos Pereira, Eliane

; Jahara Lobosco, Maria Paula

; dos Santos Andrade, Alessandra Cerqueira

; Chicharro, Sandra Conceição Ribeiro

Revista Cubana de Enfermería

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Mar 2020, Volume 36 Nº 1 elocation e3097

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Introdução: Não obstante avanços quanto ao diagnóstico da neoplasia mamária, o estigma da morte ainda se impõe. É necessário comunicação clara com a família, sendo este um desafio no cuidado pela equipe de saúde. O diagnóstico da neoplasia muda a rotina da paciente e estrutura familiar, havendo reflexão do tratamento na família; há, como consequência, repercussão negativa à mulher com câncer de mama, a depender da forma que esta percebe a influência de sua doença e prejuízos possíveis na vida de seus filhos. Objetivo: refletir vivências de mulheres com câncer mamário, em relação ao impacto de sua doença na vida dos filhos. Métodos: reflexão fundamentada em Merleau-Ponty, após revisão teórica do impacto psicológico do câncer de mama feminino na prole e sua percepção por esta mulher. Resultados: filhos, cujas mães têm câncer mamário, sobrevivem situações de estresse, relacionadas ao diagnóstico da doença materna. A mulher percebe tamanho impacto, o que repercute na vivência da patologia, sobrevindo culpa e piora do sofrimento psicológico existente em relação à doença. Para Merleau-Ponty, toda consciência é perceptiva e o mundo percebido é a base presumida de toda a racionalidade e existência. Conclusão: a iminência de morte de mães com câncer mamário pode propiciar o luto antecipatório nos filhos; a ausência destas mães, ao se dedicarem a tratamentos oncológicos, se impõe como fator de estresse à prole, trazendo maior angústia à mulher no enfrentamento da patologia.

ABSTRACT Introduction: Despite advances in the diagnosis of breast cancer, the stigma of death is imposed. Clear communication with the family is necessary, which is a care-related challenge for the health team. The diagnosis of neoplasia changes the routine and the family structure of the patient, while inducing reflection on family treatment. As a consequence, there is a negative impact on women with breast cancer, depending on how they perceive the influence of their disease and the possible damage to the lives of their children. Objective: To reflect the experiences of women with breast cancer, regarding the impact of their disease on the lives of their children. Methods: Reflection based on Merleau-Ponty, after a theoretical review of the psychological impact of female breast cancer on the offspring and the way this woman perceives the phenomenon. Results: Children whose mothers have breast cancer survive stressful situations related to the diagnosis of maternal disease. The woman perceives such impact, which affects the experience of the pathology, which results in guilt and worsening of the existing psychological suffering in relation to the disease. For Merleau-Ponty, all consciousness is perceptive and the perceived world is the presumed basis of all rationality and existence. Conclusion: The imminent death of these mothers is imposed as a stress factor for the offspring, which causes greater distress to women when facing the pathology.

RESUMEN Introducción: A pesar de los avances en el diagnóstico del cáncer de mama, el estigma de la muerte se impone. Es necesaria la comunicación clara con la familia, lo cual es un desafío en el cuidado del equipo de salud. El diagnóstico de neoplasia cambia la rutina y la estructura familiar del paciente, se reflexiona sobre el tratamiento a la familia; como consecuencia, hay una repercusión negativa para las mujeres con cáncer de mama, dependiendo de cómo perciben la influencia de su enfermedad y el posible daño a la vida de sus hijos. Objetivo: Reflejar las experiencias de las mujeres con cáncer de mama, con respecto al impacto de su enfermedad en la vida de sus hijos. Métodos: Reflexión basada en Merleau-Ponty, luego de una revisión teórica del impacto psicológico del cáncer de mama femenino en la descendencia y su percepción por parte de esta mujer. Resultados: Los niños cuyas madres tienen cáncer de mama sobreviven a situaciones de estrés relacionadas con el diagnóstico de enfermedad materna. La mujer percibe tal impacto, que afecta la experiencia de la patología, lo que resulta en culpa y empeoramiento del sufrimiento psicológico existente en relación con la enfermedad. Para Merleau-Ponty, toda conciencia es perceptiva y el mundo percibido es la base presunta de toda racionalidad y existencia. Conclusión: La muerte inminente de estas madres, se impone como un factor de estrés para la descendencia, lo que provoca una mayor angustia a las mujeres al enfrentar la patología.

13.

Application of Films Based on Chitosan and Xanthan Gum in Refrigerated Fish Conservation
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Lima, Maria de Morais

; Carneiro, Lucia Cesar

; Machado, Mírian Ribeiro Galvão

; Dias, Alvaro Renato Guerra

; Zavareze, Elessandra da Rosa

; Prentice, Carlos

; Moreira, Angelita da Silveira

Brazilian Archives of Biology and Technology

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2020, Volume 63 elocation e20190046

Resumo: En | Texto: En | PDF: En

Abstract This research aims to determine the efficiency of chitosan and xanthan gum films in conservation of croaker fillets kept in refrigeration for 9 days. Proximal composition, loss of mass, color, pH, TVB-N (Total Volatile Bases) and microbiological profile were assessed. The films were prepared with chitosan and xanthan gum in varying mass proportions 100:0, m:m (C100XG0); 60:40, m:m (C60XG40); 50:50, m:m (C50XG50). They presented the respective values for moisture content, water solubility, thickness and water vapor permeability: 24.59%, 19.50%, 0.086 mm and 11.45gm-1.s-1.Pa-1for C100XG0; 24.58%; 20.27%, 0.091 mm and 10.41 gm-1.s-1.Pa-1for C60XG40; 22.11%, 22.06%, 0.089 mm and 10.68 gm-1.s-1.Pa-1 forC50XG50.The films were made in small bags format capable to hold about 20 g of fish fillets. A control sample was prepared in parallel, using polyethylene bags under the same storage conditions. The results showed that the chitosan films combined with xanthan gum had excellent antimicrobial properties, capable of preserving the quality of chilled fish fillets during the studied period, since it inhibited the growth of Staphylococcus coagulase-positive, Salmonella spp and coliforms at 45 ° C. Mass loss of the croaker fillets was not significantly affected by xanthan gum addition to the films. On the other hand, xanthan gum addition affected pH and color parameters of the corvina fillets. It was also verified that the combination of these two polymers promoted the reduction of N-BVT, being the C50XG50 film that presented the best response.

https://doi.org/10.1590/1678-4324-2020190046 448 downloads

14.

Radiation-induced angiosarcoma: case report
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Oliveira, Lucas Aguiar Alencar de

; Pádua Filho, Antonio Fortes de

; Medeiros e Melo, Maria Adélia

; Galvão, Elisa Rosa de Carvalho Gonçalves Nunes

; Vieira, Mharcus Carneiro

; Ibiapina, Jerúsia Oliveira

; Fontinele, Danilo Rafael da Silva

; Vieira, Sabas Carlos

einstein (São Paulo)

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2020, Volume 18 elocation eRC5439

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Os angiossarcomas de mama representam menos de 1% dos tumores da mama e podem ser primários ou secundários à radioterapia prévia. Tais tumores são chamados de “angiossarcomas radiogênicos da mama” e representam uma entidade mais rara ainda e de prognóstico ruim. Atualmente, na literatura, são encontrados apenas 307 casos desses tumores. Relatamos o caso de uma mulher de 73 anos, com história prévia de tratamento conservador de câncer de mama direita, apresentando alteração rósea discreta em pele da mama homolateral. A mamografia demostrou resultado compatível com alterações benignas (BI-RADS 2). No material de biópsia incisional, a hematoxilina-eosina demonstrou lesão vascular atípica e sugeriu imuno-histoquímica para elucidação diagnóstica. A paciente foi submetida à ressecção de lesões, e a histologia demonstrou angiossarcoma radiogênico. Em seguida, mastectomia simples foi realizada. A imuno-histoquímica demonstrou positividade para os antígenos relacionados a CD31 e CD34, e a amplificação do oncogene C-MYC confirmou o diagnóstico de angiossarcoma induzido por radiação mamária. O atraso no diagnóstico constitui questão importante. Considerando que as alterações iniciais da pele do angiossarcoma radiogênico são sutis e podem ser confundidas com outras condições benignas da pele, como telangiectasias, neste relato destacamos os aspectos clínicos, no intuito de alertar sobre a possibilidade de angiossarcoma de mama em pacientes com história prévia de radioterapia adjuvante para tratamento de câncer de mama. A paciente permaneceu assintomática 16 meses após a cirurgia.

ABSTRACT Angiosarcoma of the breast accounts for less than 1% of breast tumors. This tumor may be primary or secondary to previous radiation therapy and it is also named “radiogenic angiosarcoma of the breast”, which is still a rare entity with a poor prognosis. So far, there are only 307 cases reported about these tumors in the literature. We present a case of a 73-year-old woman with a prior history of breast-conserving treatment of right breast cancer, exhibiting mild pinkish skin changes in the ipsilateral breast. Her mammography was consistent with benign alterations (BI-RADS 2). On incisional biopsy specimens, hematoxylin-eosin showed atypical vascular lesion and suggested immunohistochemisty for diagnostic elucidation. Resection of the lesions was performed and histology showed radiogenic angiosarcoma. The patient underwent simple mastectomy. Immunohistochemistry was positive for antigens related to CD31 and CD34, and C-MYC oncogene amplification, confirming the diagnosis of angiosarcoma induced by breast irradiation. A delayed diagnosis is an important concern. Initial skin changes in radiogenic angiosarcoma are subtle, therefore, these alterations may be confused with other benign skin conditions such as telangiectasia. We highlight this case clinical aspects with the intention of alerting to the possibility of angiosarcoma of the breast in patients with a previous history of adjuvant radiation therapy for breast cancer treatment. Sixteen months after the surgery the patient remains asymptomatic.

https://doi.org/10.31744/einstein_journal/2020rc5439 463 downloads

15.

Resiliência e autocuidado de pessoas idosas com diabetes mellitus
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Vicente, Mateus Carneiro

; Silva, Cleane Rosa Ribeiro da

; Pimenta, Cláudia Jeane Lopes

; Frazão, Maria Cristina Lins Oliveira

; Costa, Tatiana Ferreira da

; Costa, Kátia Neyla de Freitas Macedo

Rev Rene

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2019, Volume 20 elocation e33947

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Objective to associate resilience levels and self-care activities in elderly people with diabetes mellitus. Methods a cross-sectional study was carried out with 96 elderly patients hospitalized for complications of diabetes mellitus in medical and surgical clinics of a university hospital. Data were collected through interviews, Resilience Scale, and Diabetes Self-Care Activities Questionnaire, being analyzed by descriptive and inferential statistics. Results elderly patients with low resilience demonstrated statistically significant higher averages of week days dedicated to self-care activities such as in the axes medication, foot care, and blood glucose monitoring. Conclusion a statistical association between resilience and self-care was identified in the areas of Medication, Foot Care and Blood glucose monitoring, with evidence of higher averages among elderly patients who showed low resilience, which shows a lower adherence of these individuals to non-pharmacological activities.

Objetivo associar os níveis de resiliência e as atividades de autocuidado em pessoas idosas com diabetes mellitus. Métodos estudo transversal, realizado com 96 idosos hospitalizados por complicação do diabetes mellitus em clínicas médica e cirúrgica de hospital universitário. Coleta de dados realizada por meio de entrevista, Escala de Resiliência e Questionário de Atividades de Autocuidado com o Diabetes, sendo analisados por estatística descritiva e inferencial. Resultados idosos com baixa resiliência demonstraram maiores médias de dias na semana destinados às atividades de autocuidado nos eixos medicação, cuidado com os pés e monitorização da glicemia, sendo evidenciada significância estatística. Conclusão identificou-se associação estatística entre a resiliência e o autocuidado nos domínios Medicação, Cuidado com os pés e Monitorização da glicemia, com evidência de maiores médias entre os idosos com baixa resiliência, o que demonstra menor adesão desses indivíduos às atividades não farmacológicas.

https://doi.org/10.15253/2175-6783.20192033947 40 downloads

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